Endocrine Abstracts

A 45 year old female was referred to the Endocrinology department with complains of severe fatigue and weakness from basic daily activities, also irregular menstrual circle during last five years. Twelve years back she had twin pregnancy, premature delivery on 29th week, and absence of lactation. Afterwards she gradually lost 6 kg of her body weight and her menstrual circle become sparse and disappeared five years back. 1.5 years ago type 1 diabetes was diagnosed (C-peptide be...

Acute intermittent porphyria (AIP) is an uncommon monogenic autosomal dominant disorder with a defect in the haem biosynthesis pathway at the level of the enzyme porphobilinogen deaminase. The disease has low penetrance; most patients could stay asymptomatic throughout life. Clinical manifestation depends on various precipitants, which increase hepatic haem production and cytochrome activity. We report a case of a female patient who had regular moderate-to-severe cyclic AIP at...

Pituitary neuroendocrine tumors (PitNETs) are non-metastatic neoplasms of the pituitary that may overproduce hormones leading to systemic disorders or tumor mass effects causing headache, vertigo, or visual impairment. The overall estimated clinical prevalence of PitNETs is 1 in 400 to 1 in 1000 people. Although the pathogenesis of PitNETs has been extensively studied the molecular factors underlying tumorigenesis, remission, and therapy response of PitNETs are still unclear. ...